|
KMID : 1059519900340050476
|
|
Journal of the Korean Chemical Society
1990 Volume.34 No. 5 p.476 ~ p.482
|
|
|
Structure-Activity Relationship (Ⅰ). Conformational Analysis of 3-Phenyl-5,5-dimethyloxazolidine-2,4-diones and their Antifungal Activities
|
|
Park Seong-Sik
Yoh Soo-Dong
Chung Duck-Young
|
|
|
Abstract
|
|
|
|
The relationship between chemical structure and antifungal activity of benzene ring substituents of 3-phenyl-5,5-dimethyloxazolidine-2,4-diones is studied by testing of model compounds and use of conformational data. The analysis revealed a number of structural features as essential for the antifungal effect: (1) the presence of an intact -NCO group and benzene moiety; (2) the distance between para substituents and the N atom within the 5.32∼5.37Å range; (3) the distance between substituent X3 and X4, in the interval 5.59 ∼ 5.77 Å for the active analogues.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|